Events
BII Symposium: Quantitative Imaging in Dementia
Speakers: Karl Herholz (University of Manchester), Steve Williams (University of Manchester),
Peter Nestor (University of Cambridge) and Sebastien Ourselin (Centre for Medical Image Computing, UCL)
Date: Weds 23rd May 2012, 1pm (with lunch from 12.30-1pm)
Venue: Rooms 306a and 306b, Ground floor, Jean MacFarlane Building
This symposium draws together local and national expertise on imaging of dementia. Dementia was recently highlighted by David Cameron as ‘a quiet crisis’, and that the ‘level of diagnosis, understanding and awareness of dementia is shockingly low’. Imaging can play an important role, both in early diagnosis and in understanding the underlying brain mechanisms. The speakers will present information on how MRI and PET can be used to see changes in the gross structure, microstructure and metabolism of the brain in dementia. The symposium will include the following talks:
"Diffusion Imaging in AD and FTD" (Peter Nestor)
"Quantitative image analysis to measure disease progression in Dementia" (Sebastien Ourselin)
"The relation between atrophy, synaptic function, and amyloid deposition in Alzheimer's Disease" (Karl Herholz)
"Metabolomic Biomarkers of Alzheimer’s Disease: Investigation by Magnetic Resonance Spectroscopy of a Transgenic Mouse Model" (Steve Williams)
For more details, please see the programme.
If you would like to attend this symposium, please complete the on-line registration form.
BII Seminar: In vivo Connectivity - Paramagnetic Tracers, Electrical Stimulation & Neural-Event Triggered fMRI
Speaker: Prof Nikos Logothetis, Max Planck Institute for Biological cybernetics, Tubingen, Germany
Date: Thurs 28th June 2012, 4-5pm
Venue: Lecture Theatre 4, Stopford Building
Localizing and comprehending the neural mechanisms underlying our cognitive capacities demands concurrent study of components and networks. One way of doing this, is to combine invasive methods which afford us direct access to the brain’s electrical activity at the microcircuit level with global imaging technologies such as magnetic resonance imaging (MRI).
Capacities such as plasticity and learning are best studied with non-destructive techniques that can be applied repeatedly. The recent development of MR-visible tracers that can be infused into a specific brain region and transported is one such technique. Simultaneous electrical stimulation (ES) and fMRI (esfMRI) is another. esfMRI offers a unique opportunity for visualizing the networks underlying electrostimulation-induced behaviors, to map the neuromodulatory systems, or to study the effects of regional synaptic plasticity. In this talk Prof Logothetis will present new data on MR-visible tracers and esfMRI that show the capacity of these methods for the study of the organization of cortical microcircuits and effective connectivity. Prof Logothetis shall also show first results from studies mapping network topologies by triggering imaging at structure-specific events, e.g. hippocampal ripples or cross-frequency coupling events. This neural-event-triggered fMRI (NET-fMRI) has recently provided us with entirely new information regarding the neural networks underlying memory consolidation.
If you would like to attend this seminar, please complete the on-line registration form.